Publications

Tiwari, A., Myeong, J., Hashemiaghdam, A., Zhang, H., Niu, X., Laramie, M. A., Stunault, M.I., Sponagel, J., Patti, G., Shriver, L., Klyachko, V.A., and Ashrafi, G. (2024) Mitochondrial pyruvate transport regulates presynaptic metabolism and neurotransmission. Sci Adv. 10:eadp7423.
Myeong, J., Stunault, M.I., Klyachko, V.A.^#, Ashrafi G.^# (2024) Metabolic regulation of single synaptic vesicle exo- and endocytosis in hippocampal synapses. Cell Reports 43, 114218. ^#equal contribution
Tiwari, A., Hashemiaghdam, A., Laramie, M.A., Maschi, D., Haddad, T., Stunault, M.I., Bergom, C., Javaheri, A., Klyachko, V.A., and Ashrafi, G. (2024) Sirtuin3 ensures the metabolic plasticity of neurotransmission during glucose deprivation. Journal of Cell Biology 223:e202305048.
LaPak, K.M., Saeidi, S., Bok, I., Wamsley, N.T., Plutzer, I.B., Bhatt, D.P., Luo, J., Ashrafi, G., Major, B.M. (2023) Proximity proteomic analysis of the NRF family reveals the Parkinson’s disease protein ZNF746/PARIS as a co-complexed repressor of NRF2. Sci Signal. 16(815):eadi9018.
Marion I. Stunault, M.I, and Ashrafi, G. Synaptosomes and synaptic vesicles –Encyclopedia of cell Biology (Second Edition), 2022, Volume 2, 2023, Pages 363-377.
Dehkharghanian, T., Hashemiaghdam, A. and Ashrafi, G. Semi-automated analysis of an optical ATP indicator in neurons. (2022) Semi-automated analysis of an optical ATP indicator in neurons. Neurophotonics 2021.2009.2020.461141.
Harbauer, A.B., Wanderoy, S., Hees T.J., Gibbs, W., Ordonez, M., Cai, Z., Cartoni, R., Ashrafi, G., Wang, C., He, Z., and Schwarz, T.L. (2022) Neuronal mitochondria transport Pink1 mRNA via Synaptojanin 2 to support local mitophagy. Neuron 110: 1516-1531.
Mahadevan, H.M., Hashemiaghdam, A., Ashrafi, G., and Harbauer, A.B. (2021). Mitochondria in neuronal energy metabolism and neurodegeneration. Adv Biol. (Weinh) e2100663.
^#Ashrafi, G., ^#de Juan-Sanz, J., Farrell, R. J., and Ryan, T.A. (2020) Molecular tuning of the axonal mitochondrial Ca²⁺ uniporter ensures metabolic flexibility of neurotransmission. Neuron 105: 1-10. ^#equal contribution
Koopmans, F.,…, Ashrafi, G.,…, Verhage, M. (2019) SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse. Neuron 103: 1-18.
Ashrafi, G., and Ryan, T.A. (2017) Glucose metabolism in nerve terminals. Curr. Opin. Neurobiol. 45:156-161.
Ashrafi, G., Wu, J., Farrell, R.J., and T.A. Ryan. (2017) GLUT4 mobilization supports energetic demands of active synapses. Neuron 93: 606-615.
Cao, M., Wu, Y., Ashrafi, G., McCartney, A.J., Wheeler, H., Bushong, E.A., Boassa, D., Ellisman, M.H., Ryan, T.A., and P. De Camilli. (2017) Parkinson Sac domain mutation in Synaptojanin 1 impairs clathrin uncoating at synapses and triggers dystrophic changes in dopaminergic axons. Neuron 93: 882-896.
Ashrafi, G., and Schwarz, T.L. (2015) PINK1- and Parkin-mediated local mitophagy in distal neuronal axons. Autophagy 11:187-9.
Gorski, P., Trieber CA., Ashrafi, G., and Young, H.S. (2015) Regulation of the sarcoplasmic reticulum calcium pump by divergent phospholamban isoforms in zebrafish. Journal of Biological Chemistry 290:6777-88.
Ashrafi, G., Schlehe, J.S., LaVoie. M.J., and Schwarz, T.L. (2014) Axonal mitophagy is initiated locally in distal neuronal axons and requires PINK1 and Parkin. Journal of Cell Biology 206: 655-70.
Ashrafi, G., and Schwarz, T.L. (2012) The pathways of mitophagy for quality control and clearance of mitochondria. Cell Death Differ. 20:31-42.
Wang, X., Winter, D., Ashrafi, G., Schlehe, J., Steen J., LaVoie, M., Selkoe, D., Wong, Y., Rice, S., and Schwarz, T.L. (2011) PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility. Cell 147:893-906.