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Semi-automated analysis of an optical ATP indicator in neural synapses

Neutrophonics

Sirtuin3 ensures the metabolic plasticity of neurotransmission during glucose deprivation

Journal of Cell Biology

Proximity proteomic analysis of the NRF family reveals the Parkinson’s disease protein ZNF746/PARIS as a co-complexed repressor of NRF2

Science Signaling

Neuronal mitochondria transport Pink1 mRNA via Synaptojanin 2 to support local mitophagy.

Neuron

Mitochondria in neuronal energy metabolism and neurodegeneration.

Advanced Biology

Molecular tuning of the axonal mitochondrial Ca2+ uniporter ensures metabolic flexibility in neurotransmission.

Neuron

SynGO: An evidence-based, expert-curated knowledge base for the synapse.

Neuron

Glucose metabolism in nerve terminals.

Current Opinion in Neurobiology

GLUT4 mobilization supports energetic demands of active synapses.

Neuron

Parkinson Sac domain mutation in Synaptojanin 1 impairs clathrin uncoating at synapses and triggers dystrophic changes in dopaminergic axons.

Neuron

PINK-1 and Parkin-mediated local mitophagy in distal neuronal axons.

Autophagy

Regulation of the sarcoplasmic reticulum calcium pump by divergent phospholamban isoforms in zebrafish.

Journal of Biological Chemistry

Axonal mitophagy is initiated locally in distal neuronal axons and requires PINK1 and Parkin.

Journal of Cell Biology

The pathways of mitophagy for quality control and clearance of mitochondria.

Cell Death & Differentiation

PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility.

Cell

Ashrafi Lab

Department of Cell Biology & Physiology

660 S. Euclid Ave

McDonnell Sciences Building

St. Louis, MO 63110

314-273-1870

ghazaleh@wustl.edu

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